Alkylaminopropenones and Alkylamino-Propenoates as Efficient and Versatile Synthons in Microwave-Assisted Combinatorial Synthesis

Author(s): J. Westman, R. Lundin, J. Stalberg, M. Ostbye, A. Franzen, A. Hurynowicz

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 5 , Issue 7 , 2002

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A simple and fast one-pot method using microwave irradiation for the synthesis of a number of small libraries of diverse heterocycles is described in this paper. The two-step one-pot method includes the formation of alkylaminopropenones or alkylaminopropenoates in 5 min at 180°C and a subsequent treatment with dinucleophiles for 3 to 5 min at 150°C to 180°C to form a variety of biologically interesting heterocycles in a cascade-type reaction. The combination of combinatorial chemistry and microwave-assisted synthesis was found to be very efficient.

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Article Details

Year: 2002
Page: [565 - 570]
Pages: 6
DOI: 10.2174/1386207023330048
Price: $65

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