Identification of Novel α-Glucosidase Inhibitors by Screening Libraries Based on N- [4-(Benzyloxy) Benzoyl] Alanine Derivatives [1]

Author(s): B. Kundu, S. K. Rastogi, R. Ahmad, A.K. Srivastava

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 5 , Issue 7 , 2002

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Abstract:

A library of 72 compounds related to N- [4-(benzyloxy) benzoyl]alanine (I) was synthesized, prepared and screened for α-glucosidase inhibitory activity. Four compounds showed potent inhibition, six compounds moderate inhibition, and 16 were weak inhibitors. One compound, N- [4-(benzyloxy) benzoyl] serine, was found to be a potent inhibitor of α-glucosidase with 100% inhibition at 1μM. This inhibitor was at least five times more potent than the lead compound I.

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Article Details

VOLUME: 5
ISSUE: 7
Year: 2002
Page: [545 - 550]
Pages: 6
DOI: 10.2174/1386207023330020
Price: $65

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