Abstract
The interactions of various low-molecular weight substances with DNA are naturally relevant mechanisms in the cellular cycle and so also used in medicinal treatment. Depending on the particular drug structure, DNA-binding modes like groove-binding, intercalating and / or stacking, give rise to supramolecular assemblies of the polynucleotides, as well as influence the DNA-protein binding. In this review, we compare the underlying molecular structures, including general aspects of DNA sequences, with the benefit in medicinal treatment. While so far interest in this field had mainly been devoted to isolated nucleic acid / drug interactions, the present paper will focus on drug efficiencies generating and influencing supramolecular organizations and their complex sequence-dependent structure-activity codes. In particular, the attention will be directed to stereoelectronic relationships. Spatial enantioselective properties are discussed in details. As examples, the drug self-assemblies, as well as the influence of drugs on supramolecular DNA formations are described. A hypothetical connection between drug-influenced DNA-toroids and the formation of micronuclei in tissues will be interpreted.
Keywords: DNA-Binding, daunomycin derivative, Ec hinomycin, Pa clitaxe l, Groove Binding, 4-hydroxyphenyl ring
Current Medicinal Chemistry
Title: DNA-Binding of Drugs Used in Medicinal Therapies
Volume: 9 Issue: 3
Author(s): G. Bischoff and S. Hoffmann
Affiliation:
Keywords: DNA-Binding, daunomycin derivative, Ec hinomycin, Pa clitaxe l, Groove Binding, 4-hydroxyphenyl ring
Abstract: The interactions of various low-molecular weight substances with DNA are naturally relevant mechanisms in the cellular cycle and so also used in medicinal treatment. Depending on the particular drug structure, DNA-binding modes like groove-binding, intercalating and / or stacking, give rise to supramolecular assemblies of the polynucleotides, as well as influence the DNA-protein binding. In this review, we compare the underlying molecular structures, including general aspects of DNA sequences, with the benefit in medicinal treatment. While so far interest in this field had mainly been devoted to isolated nucleic acid / drug interactions, the present paper will focus on drug efficiencies generating and influencing supramolecular organizations and their complex sequence-dependent structure-activity codes. In particular, the attention will be directed to stereoelectronic relationships. Spatial enantioselective properties are discussed in details. As examples, the drug self-assemblies, as well as the influence of drugs on supramolecular DNA formations are described. A hypothetical connection between drug-influenced DNA-toroids and the formation of micronuclei in tissues will be interpreted.
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Cite this article as:
Bischoff G. and Hoffmann S., DNA-Binding of Drugs Used in Medicinal Therapies, Current Medicinal Chemistry 2002; 9 (3) . https://dx.doi.org/10.2174/0929867023371085
DOI https://dx.doi.org/10.2174/0929867023371085 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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