Integration of NMR and High-Throughput Screening

Author(s): Philip J. Hajduk, David J. Burns

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 5 , Issue 8 , 2002

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NMR-based screening has become a powerful method for the identification and analysis of lowmolecular weight organic compounds that bind to protein targets and can be utilized in drug discovery programs. In particular, heteronuclear NMR-based screening can yield information about both the affinity and binding location of potential lead compounds. In addition, heteronuclear NMR-based screening has wide applications in complementing and facilitating conventional high-throughout screening programs. This article will describe several strategies for the integration of NMR-based screening and high-throughput screening. The marriage of these two techniques promises to be of tremendous benefit in the triage of hits that come from HTS, and can aid the medicinal chemist in the identification of quality leads that have high potential for further optimization.

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Article Details

Year: 2002
Page: [613 - 621]
Pages: 9
DOI: 10.2174/1386207023329996
Price: $65

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