Integration of NMR and High-Throughput Screening

Title: Integration of NMR and High-Throughput Screening

Volume: 5 Issue: 8

Author(s): Philip J. Hajduk and David J. Burns

Affiliation:

Abstract: NMR-based screening has become a powerful method for the identification and analysis of lowmolecular weight organic compounds that bind to protein targets and can be utilized in drug discovery programs. In particular, heteronuclear NMR-based screening can yield information about both the affinity and binding location of potential lead compounds. In addition, heteronuclear NMR-based screening has wide applications in complementing and facilitating conventional high-throughout screening programs. This article will describe several strategies for the integration of NMR-based screening and high-throughput screening. The marriage of these two techniques promises to be of tremendous benefit in the triage of hits that come from HTS, and can aid the medicinal chemist in the identification of quality leads that have high potential for further optimization.

Cite this article as:

Philip J. Hajduk and David J. Burns , Integration of NMR and High-Throughput Screening, Combinatorial Chemistry & High Throughput Screening 2002; 5 (8) . https://dx.doi.org/10.2174/1386207023329996