Abstract
A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A4 hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.
Keywords: hydroxamic acids, arthritis, matrix metalloproteinases, lipoxigenases, peptide deformilases, succiny1 hydroxamates, angiotensin converting enzyme, zinc metalloenzyme, inflammatory response, helicobacter pylori
Current Medicinal Chemistry
Title: Hydroxamic Acids as Pharmacological Agents
Volume: 9 Issue: 17
Author(s): E. M.F. Muri, M. J. Nieto, R. D. Sindelar and J. S. Williamson
Affiliation:
Keywords: hydroxamic acids, arthritis, matrix metalloproteinases, lipoxigenases, peptide deformilases, succiny1 hydroxamates, angiotensin converting enzyme, zinc metalloenzyme, inflammatory response, helicobacter pylori
Abstract: A variety of hydroxamic acid derivatives have recently been touted for their potential use as inhibitors of hypertension, tumor growth, inflammation, infectious agents, asthma, arthritis, and more. Here we provide a comprehensive review of the basic medicinal chemistry and pharmacology of hydroxamic acid derivatives that have been examined as inhibitors of zinc metalloproteases, matrix metalloproteinases, leukotriene A4 hydrolases, ureases, lipoxigenases, cyclooxygenases, as well as peptide deformilases.
Export Options
About this article
Cite this article as:
Muri M.F. E., Nieto J. M., Sindelar D. R. and Williamson S. J., Hydroxamic Acids as Pharmacological Agents, Current Medicinal Chemistry 2002; 9 (17) . https://dx.doi.org/10.2174/0929867023369402
DOI https://dx.doi.org/10.2174/0929867023369402 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Adiposity and Alzheimers Disease
Current Alzheimer Research Electrochemical Behavior of Indole-3-Carboxaldehyde Izonicotinoyl Hydrazones: Discussion on Possible Biological Behavior
Combinatorial Chemistry & High Throughput Screening Gene-Gene and Gene-Environment Interplay Represent Specific Susceptibility for Different Types of Ischaemic Stroke and Leukoaraiosis
Current Medicinal Chemistry Clinical Approach for the Treatment of Obesity-associated Diseases
Current Pharmaceutical Design Detecting the Association Between Residual Thrombus and Post-thrombotic Classification of Chronic Venous Disease with Range Regression
Reviews on Recent Clinical Trials Pleiotropic, Cardioprotective Effects of Omega-3 Polyunsaturated Fatty Acids
Mini-Reviews in Medicinal Chemistry Peroxisome Proliferator-Activated Receptors and the Control of Fatty Acid Oxidation in Cardiac Hypertrophy
Mini-Reviews in Medicinal Chemistry Pupil Response Biomarkers Distinguish Amyloid Precursor Protein Mutation Carriers from Non-Carriers
Current Alzheimer Research Editorial [ Has the Time Come for a New Definition of Microalbuminuria? ]
Current Vascular Pharmacology Pulmonary Hypertension in Cardiac Surgery
Current Cardiology Reviews Conference Report (8th Annual Meeting of the Society for the Study of Neuroprotection and Neuroplasticity)
CNS & Neurological Disorders - Drug Targets Nontraditional Cardiovascular Risk Factors in Pediatric Type 1 Diabetes
Current Diabetes Reviews TRPM6 and TRPM7: A Mul-TRP-PLIK-Cation of Channel Functions
Current Pharmaceutical Biotechnology Isometric Handgrip Effects on Hypertension
Current Hypertension Reviews The Role of ROS and RNS in Regulating Life and Death of Blood Monocytes
Current Pharmaceutical Design Testing of Compounds in Models of Pulmonary Emphysema
Current Medicinal Chemistry ENaC and Its Regulatory Proteins as Drug Targets for Blood Pressure Control
Current Drug Targets Physiological Mechanisms of Action of Incretin and Insulin in Regulating Skeletal Muscle Metabolism
Current Diabetes Reviews Ultrasonic-Promoted One-Pot Synthesis of 4H-chromenes, pyrano[2,3- d]pyrimidines, and 4H-pyrano[2,3-c]pyrazoles
Letters in Organic Chemistry Preface [Hot Topic: Exogenous Factors Affecting Cardiovascular and Hematological Targets (Guest Editor: R. Manjunatha Kini)]
Current Drug Targets - Cardiovascular & Hematological Disorders