Abstract
Oxidative damage is shown to affect every class of biological macromolecule in Alzheimer disease. Disruptions in iron and copper homeostasis are understood as being key players in neurodegenerative disease pathogenesis. Metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases is reviewed here with its relations to oxidative stress. While there is substantial documented evidence for alterations in transition metal metabolism, redox-activity and localization, it is also important to note that alterations in specific copper- and iron-containing metalloenzymes also contribute to the neurodegenerative process. Understanding these changes offers the opportunity to identify pathways where modification of the disease process can offer effective clinical intervention, from gene therapy to pharmaceuticals with antioxidant and chelating properties.
Keywords: neurodegenerative disease, antioxidant, chelating properties, pathogenesis of alzheimer disease, copper homeostasis, iron mediated oxidative damage
Current Medicinal Chemistry
Title: Therapeutic Potential in Alzheimer Disease
Volume: 9 Issue: 17
Author(s): A. D. Cash, G. Perry and M. A. Smith
Affiliation:
Keywords: neurodegenerative disease, antioxidant, chelating properties, pathogenesis of alzheimer disease, copper homeostasis, iron mediated oxidative damage
Abstract: Oxidative damage is shown to affect every class of biological macromolecule in Alzheimer disease. Disruptions in iron and copper homeostasis are understood as being key players in neurodegenerative disease pathogenesis. Metal homeostasis as it pertains to alterations in brain function in neurodegenerative diseases is reviewed here with its relations to oxidative stress. While there is substantial documented evidence for alterations in transition metal metabolism, redox-activity and localization, it is also important to note that alterations in specific copper- and iron-containing metalloenzymes also contribute to the neurodegenerative process. Understanding these changes offers the opportunity to identify pathways where modification of the disease process can offer effective clinical intervention, from gene therapy to pharmaceuticals with antioxidant and chelating properties.
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Cite this article as:
Cash D. A., Perry G. and Smith A. M., Therapeutic Potential in Alzheimer Disease, Current Medicinal Chemistry 2002; 9 (17) . https://dx.doi.org/10.2174/0929867023369411
DOI https://dx.doi.org/10.2174/0929867023369411 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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