Non-peptide Opioid Receptor Ligands - Recent Advances. Part II - Antagonists

Author(s): Agnieszka Kaczor, Dariusz Matosiuk

Journal Name: Current Medicinal Chemistry

Volume 9 , Issue 17 , 2002


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Abstract:

This paper is the second part of the review on opioid receptor ligands and deals with the progress in the field of non-peptide opioid receptor antagonists (starting from the pioneering opiate studies in the early seventies) with particular stress on the last decade accomplishments. As X-ray high resolution structure determination of the ligand-receptor systems for G protein-coupled receptors meets with considerable experimental obstacles, the knowledge about ligand interactions with the membrane-bound receptors traditionally derives from structure-activity studies. Hence, such a concise summary, collecting chemically distinct but pharmalogically relative compounds, may be a convenient information source for any research concerning ligand-opioid receptor binding or rational drug design.

Keywords: non-peptide opioid receptor, norbinaltorphimine derived ligands, de novo methodology, pharmacophore models, pyrrolomorphinans, kappa opioid receptor

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Article Details

VOLUME: 9
ISSUE: 17
Year: 2002
Page: [1591 - 1603]
Pages: 13
DOI: 10.2174/0929867023369358
Price: $65

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