Cytokine Polymorphisms in Chronic Inflammatory Diseases with Reference to Occupational Diseases

Author(s): Berran Yucesoy, Michael L. Kashon, Michael I. Luster

Journal Name: Current Molecular Medicine

Volume 3 , Issue 1 , 2003

Become EABM
Become Reviewer
Call for Editor


Genes which encode inflammatory cytokines are subject to polymorphisms in their regulatory regions that may effect both the level and ratio of cytokines produced in response to exogenous stimuli. These variant alleles are observed in a large percent of the population and are often associated with increased or decreased susceptibility or severity (modifiers) to infectious, immune or inflammatory diseases. Environmental factors can also play either a direct (i.e., causative factor) or indirect (modifying factor) role in these diseases. Thus, it would follow that gene-environment interactions would effect the expression and / or progression of the disease. In the present review, the concept that some of the common allelic variants found in cytokine genes represent modifying factors in chronic inflammatory diseases associated with occupational exposure is discussed.

Keywords: single nucleotide polymorphisms, cytokine network, chronic inflammatory diseases, occupational diseases, cytokine polymorphisms

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2003
Page: [39 - 48]
Pages: 10
DOI: 10.2174/1566524033361582
Price: $65

Article Metrics

PDF: 18