Purine and Sugar Chemistry on Solid Phase - 100 Years After the Emil Fischers Chemistry Nobel Prize 1902

Author(s): Robert Franzen, Jan Tois

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 6 , Issue 5 , 2003

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The Nobel Prize in Chemistry 1902 was given to Hermann Emil Fischer “in recognition of the extraordinary services he had rendered by his work on sugar and purine synthesis”. This truly great chemist of all time named a group of bicyclic nitrogenous structures as purines, discovered the synthesis of glucose, fructose and mannose starting from glycerol, and further created the basis for glucoside-, amino acid-, and enzyme chemistry. To honour his discoveries, and to celebrate the 100 year since his Nobel Prize, we decided to write a short review article on the latest discoveries in the fields of purine / pyrimidine and sugar chemistry beeing performed on solid support. The review summarizes most of the material beeing published in the field since 1960, and ends by giving a picture of future directions for the field of drug discovery based on sugar and purine chemistry.

Keywords: sugar chemistry, emil fischer chemistry, bicyclic nitrogenous structures, pyrimidine chemistry

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Article Details

Year: 2003
Page: [433 - 444]
Pages: 12
DOI: 10.2174/138620703106298617
Price: $65

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