Abstract
Influenza is a highly contagious, acute upper respiratory tract disease caused by influenza virus, a member of the Orthomyxoviridae family. The viral particles have two surface antigens, haemagglutinin and sialidase (neuraminidase) that extensively decorate the surface of the virus and have been implicated in viral attachment and fusion, and the release of virion progeny, respectively. The receptor for haemagglutinin is the terminal sialic acid residue of host cell surface sialyloligosaccharides, while sialidase catalyses the hydrolysis of terminal sialic acid residues from sialyloligosaccharides. Extensive crystallographic studies of both these proteins have revealed that the residues that interact with the sialic acid are strictly conserved. Therefore, these proteins make attractive targets for the design of drugs to halt the progression of the virus. Recent successful efforts in the search for new cures for influenza have led to the development of three clinically-useful anti-influenza drugs. All three are potent, selective inhibitors of influenza virus A and B sialidase. Strategies for the development of haemagglutinin inhibitors have also been devised.
Keywords: anti-influenza therapies, Influenza, influenza virus, haemagglutinin inhibitors
Current Drug Targets
Title: Recent Strategies in the Search for New Anti-Influenza Therapies
Volume: 4 Issue: 5
Author(s): J. C. Wilson and M. von Itzstein
Affiliation:
Keywords: anti-influenza therapies, Influenza, influenza virus, haemagglutinin inhibitors
Abstract: Influenza is a highly contagious, acute upper respiratory tract disease caused by influenza virus, a member of the Orthomyxoviridae family. The viral particles have two surface antigens, haemagglutinin and sialidase (neuraminidase) that extensively decorate the surface of the virus and have been implicated in viral attachment and fusion, and the release of virion progeny, respectively. The receptor for haemagglutinin is the terminal sialic acid residue of host cell surface sialyloligosaccharides, while sialidase catalyses the hydrolysis of terminal sialic acid residues from sialyloligosaccharides. Extensive crystallographic studies of both these proteins have revealed that the residues that interact with the sialic acid are strictly conserved. Therefore, these proteins make attractive targets for the design of drugs to halt the progression of the virus. Recent successful efforts in the search for new cures for influenza have led to the development of three clinically-useful anti-influenza drugs. All three are potent, selective inhibitors of influenza virus A and B sialidase. Strategies for the development of haemagglutinin inhibitors have also been devised.
Export Options
About this article
Cite this article as:
Wilson C. J. and Itzstein von M., Recent Strategies in the Search for New Anti-Influenza Therapies, Current Drug Targets 2003; 4 (5) . https://dx.doi.org/10.2174/1389450033491019
DOI https://dx.doi.org/10.2174/1389450033491019 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Nutrition Intervention for Undernourished Older Adults amid the
COVID-19 Pandemic
Current Nutrition & Food Science Serum Procalcitonin Levels in Febrile Patients with Systemic Autoimmune Diseases
Current Rheumatology Reviews A Review on Anti-urease Potential of Coumarins
Current Drug Targets Pharmacological Modulation of Caspase Activation
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Discovery, SAR and Medicinal Chemistry of Herpesvirus Helicase Primase Inhibitors
Current Medicinal Chemistry - Anti-Infective Agents Compounds Containing Azole Scaffolds as Cyclooxygenase Inhibitors: A Review
Current Topics in Medicinal Chemistry Ring-Fused Thiadiazines as Core Structures for the Development of Potent AMPA Receptor Potentiators
Current Medicinal Chemistry Meet Our Co-Editor
Current Enzyme Inhibition Imaging Features of Thoracic Manifestations of Behçet’s Disease: Beyond Pulmonary Artery Involvement
Current Medical Imaging Soft Antibacterial Agents
Current Medicinal Chemistry The Many Faces of Glutathione Transferase Pi
Current Molecular Medicine UDP-3-O-(R-3-hydroxymyristoyl)-N-Acetylglucosamine Deacetylase (LpxC) Inhibitors: A New Class of Antibacterial Agents
Current Medicinal Chemistry A2A Receptor Ligands: Past, Present and Future Trends
Current Topics in Medicinal Chemistry Quantum Mechanical Methods for Drug Design
Current Topics in Medicinal Chemistry Prediction Oriented QSAR Modelling of EGFR Inhibition
Current Medicinal Chemistry Recent Approaches and Success of Liposome-Based Nano Drug Carriers for the Treatment of Brain Tumor
Current Drug Delivery Imaging of Integrins as Biomarkers for Tumor Angiogenesis
Current Pharmaceutical Design Targeting of Low-Molecular Weight Drugs to Mammalian Mitochondria
Drug Design Reviews - Online (Discontinued) Docking-Based Virtual Screening: Recent Developments
Combinatorial Chemistry & High Throughput Screening Hydroxychloroquine Sulfate (Plaquenil): A Possible Candidate for Pandemic SARS-CoV-2 or (COVID-19) ?
Coronaviruses