Abstract
Hepatoma Derived Growth Factor (HDGF) was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. Although initially thought to be a cytoplasmic protein, it became clear that HDGF is a nuclear targeted protein containing a canonical bipartite nuclear localization sequence. In the developing vasculature HDGF is highly expressed in the nucleus of smooth muscle and endothelial cells. HDGF expression in smooth muscle in particular, declines after birth in larger arteries only to be re-expressed with vascular injury in cells of the highly proliferative neointima. In addition, levels of HDGF have recently been shown to be elevated in a number of cancers, suggesting a potential role in cancer development. Because of these roles, HDGF is a potential target for drug design. This review will describe current knowledge about the biochemical functioning of the protein and identify potential avenues for drug development.
Keywords: vascular disease, pwwp, hdgf, growth factors
Current Drug Targets
Title: Hepatoma Derived Growth Factor is a Nuclear Targeted Mitogen
Volume: 4 Issue: 5
Author(s): Allen D. Everett and John Bushweller
Affiliation:
Keywords: vascular disease, pwwp, hdgf, growth factors
Abstract: Hepatoma Derived Growth Factor (HDGF) was originally identified as a secreted mitogen from the human hepatoma cell line Huh-7. Although initially thought to be a cytoplasmic protein, it became clear that HDGF is a nuclear targeted protein containing a canonical bipartite nuclear localization sequence. In the developing vasculature HDGF is highly expressed in the nucleus of smooth muscle and endothelial cells. HDGF expression in smooth muscle in particular, declines after birth in larger arteries only to be re-expressed with vascular injury in cells of the highly proliferative neointima. In addition, levels of HDGF have recently been shown to be elevated in a number of cancers, suggesting a potential role in cancer development. Because of these roles, HDGF is a potential target for drug design. This review will describe current knowledge about the biochemical functioning of the protein and identify potential avenues for drug development.
Export Options
About this article
Cite this article as:
Everett D. Allen and Bushweller John, Hepatoma Derived Growth Factor is a Nuclear Targeted Mitogen, Current Drug Targets 2003; 4 (5) . https://dx.doi.org/10.2174/1389450033490975
DOI https://dx.doi.org/10.2174/1389450033490975 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Tailoring Particle Microstructures via Supercritical CO<sub>2</sub> Processes for Particular Drug Delivery
Current Pharmaceutical Design Treatment of MDR1 Mutant Dogs with Macrocyclic Lactones
Current Pharmaceutical Biotechnology Targeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective Strategy to Inhibit Tumor Cell Proliferation
Current Cancer Drug Targets Synergistic Interplay of Medicinal Chemistry and Formulation Strategies in Nanotechnology – From Drug Discovery to Nanocarrier Design and Development
Current Topics in Medicinal Chemistry Canine Nutritional Model: Influence of Age, Diet, and Genetics on Health and Well-Being
Current Nutrition & Food Science Molecular Modeling Applied to Anti-Cancer Drug Development
Anti-Cancer Agents in Medicinal Chemistry Microalgal Fatty Acids and Their Implication in Health and Disease
Mini-Reviews in Medicinal Chemistry Stochastic Neighbor Embedding Algorithm and its Application in Molecular Biological Data
Current Bioinformatics Role of the RAS in Pancreatic Cancer
Current Cancer Drug Targets Drug-Induced Peripheral Neuropathy: Diagnosis and Management
Current Cancer Drug Targets Natural Fused Heterocyclic Flavonoids: Potent Candidates as Anti- Inflammatory and Anti-Allergic Agents in the Treatment of Asthma
Current Bioactive Compounds Production of Alpha Emitters for Targeted Alpha Therapy
Current Radiopharmaceuticals Induction of Molecular Chaperones as a Therapeutic Strategy for the Polyglutamine Diseases
Current Pharmaceutical Biotechnology Ghrelin and Motilin in the Gastrointestinal System
Current Pharmaceutical Design Molecular Mechanism of Resistance to Chemotherapy in Gastric Cancers, the Role of Autophagy
Current Drug Targets Lymphatic Targeting of Nanosystems for Anticancer Drug Therapy
Current Pharmaceutical Design Biopolymer-Based Delivery Systems: Challenges and Opportunities
Current Topics in Medicinal Chemistry The Role of Oxaliplatin-Based Versus Cisplatin-Based Regimens in Advanced Gastric Cancer: A Systematic Review and Pooled Analysis of the Chinese Literature
Current Cancer Therapy Reviews Germacrone: A Potent Secondary Metabolite with Therapeutic Potential in Metabolic Diseases, Cancer and Viral Infections
Current Drug Metabolism Smart Stimuli Sensitive Nanogels in Cancer Drug Delivery and Imaging: A Review
Current Pharmaceutical Design