Tetraacyldiborates: Selective and Efficient Acylation Reagents Suitable for Multiple Parallel Synthetic Applications

Author(s): Elmer J. Gentry, Hanumaiah Telikepalli, Pusuluri Srinivas, Lester A. Mitscher

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 6 , Issue 2 , 2003

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Boron-based mixed anhydrides are rapidly reactive, easy to prepare, cheap, efficient, and general acylating reagents capable of selectivity when chelation is possible. High yields of various esters, amides and thioesters are quickly obtainable and the products are easy to isolate in high purity. The method is readily used under multiple parallel synthesis conditions and is readily scaleable.

Keywords: Tetraacyldiborates, Acylation Reagents, Boron-based, anhydrides, chelation

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Article Details

Year: 2003
Page: [139 - 145]
Pages: 7
DOI: 10.2174/1386207033329797
Price: $65

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