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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Tetraacyldiborates: Selective and Efficient Acylation Reagents Suitable for Multiple Parallel Synthetic Applications

Author(s): Elmer J. Gentry, Hanumaiah Telikepalli, Pusuluri Srinivas and Lester A. Mitscher

Volume 6, Issue 2, 2003

Page: [139 - 145] Pages: 7

DOI: 10.2174/1386207033329797

Price: $65

Abstract

Boron-based mixed anhydrides are rapidly reactive, easy to prepare, cheap, efficient, and general acylating reagents capable of selectivity when chelation is possible. High yields of various esters, amides and thioesters are quickly obtainable and the products are easy to isolate in high purity. The method is readily used under multiple parallel synthesis conditions and is readily scaleable.

Keywords: Tetraacyldiborates, Acylation Reagents, Boron-based, anhydrides, chelation


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