Small Interfering RNA: A New Tool for Gene Therapy

Author(s): Feng Bi, Na Liu, Daiming Fan

Journal Name: Current Gene Therapy

Volume 3 , Issue 5 , 2003


Become EABM
Become Reviewer
Call for Editor

Abstract:

The use of anti-gene agents to disrupt the expression of disease-related genes could potentially be of utility in the treatment of a large number of illnesses, including most neoplasms. Traditional anti-gene agents include antisense oligonucleotides and ribozymes. Recent observations have provided evidence for another promising anti-gene technology-RNA interference (RNAi), in which the introduced double-stranded RNA (dsRNA), after a complicated series of processing steps, disrupts the expression of the targeted cellular gene. Further studies have indicated that small interfering RNAs (siRNAs) of generally 21 ∼ 23 nucleotides, which resemble the processing products of long dsRNA, can induce RNAi directly in mammalian cells. Because of their high specificity and efficiency, siRNAs might be a new class of anti-gene medicines for gene therapy applications.

Keywords: Gene Therapy, anti-gene medicines, oligonucleotides, ribozymes

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 3
ISSUE: 5
Year: 2003
Page: [411 - 417]
Pages: 7
DOI: 10.2174/1566523034578203
Price: $65

Article Metrics

PDF: 3