Chemokines in Cardiovascular Remodeling: Clinical and Therapeutic Implications

Author(s): Gerasimos Filippatos, John T. Parissis, Stamatis Adamopoulos, Fotios Kardaras

Journal Name: Current Molecular Medicine

Volume 3 , Issue 2 , 2003

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Abstract:

Chemokines are newly discovered molecules that mediate the migration of leukocytes into inflammed tissues and control the inflammatory reactions in various immune-mediated diseases. Both in animal models and in human specimens, chemokine expression is associated with atherosclerotic lesion development and vascular remodeling and restenosis after angioplasty. Furthermore, recent studies have demonstrated that chemokines play an important role in the pathophysiology of acute coronary syndromes, post-infarction left ventricular remodeling and chronic heart failure. The capacity to control activation and movement of inflammatory cells suggests that chemokines and their receptors might provide novel targets for therapeutic intervention in a number of conditions characterized by chronic inflammation, including cardiovascular diseases. The present review summarizes current knowledge regarding the potential pathogenic role of chemokines in major cardiovascular disorders, as well as the modulation of the chemokine network as a novel, interesting therapeutic modality in this field.

Keywords: Chemokines, chemokine network, angioplasty, cardiovascular

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2003
Page: [139 - 147]
Pages: 9
DOI: 10.2174/1566524033361546
Price: $65

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