Synthetic Oligosaccharides as Heparin-Mimetics Displaying Anticoagulant Properties

Author(s): Fikri Y. Avci, Nathalie A. Karst, Robert J. Linhardt

Journal Name: Current Pharmaceutical Design

Volume 9 , Issue 28 , 2003

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Abstract:

Heparin and low molecular weight heparins are major clinical anticoagulants and the drugs of choice for the treatment of deep venous thrombosis. The discovery of an antithrombin binding domain in heparin focused interest on understanding the mechanism of heparins antithrombotic / anticoagulant activity. Various heparin-mimetic oligosaccharides have been prepared in an effort to replace polydisperse heparin and low molecular weight heparins with a structurally-defined anticoagulant. The goal of attaining a heparin-mimetic with no unwanted side-effects has also provided motivation for these efforts. This article reviews structure-activity relationship (SAR) of structurally-defined heparin-mimetic oligosaccharides.

Keywords: heparin, anticoagulant, antithrombotic, antithrombin III, heparin pentasaccharide, factor xa, thrombin, bisaldonic acid amides

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Article Details

VOLUME: 9
ISSUE: 28
Year: 2003
Page: [2323 - 2335]
Pages: 13
DOI: 10.2174/1381612033453929
Price: $65

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