Emerging Understanding of the Advantage of Small Molecules such as Hydroxypyridinones in the Treatment of Iron Overload

Author(s): Robert C. Hider, Zu D. Liu

Journal Name: Current Medicinal Chemistry

Volume 10 , Issue 12 , 2003


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Abstract:

Deferiprone, a hydroxypyridin-4-one, is effective at facilitating iron removal from iron overloaded patients, when administered orally. Some problems associated with deferiprone are discussed. Hydroxypyridinone analogues with improved distribution, metabolism and affinity for iron are described. In particular the “high pFe3+” hydroxypyridin-4-ones possess considerable clinical potential.

Keywords: iron chelators, hydroxypyridinone, prodrug

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Article Details

VOLUME: 10
ISSUE: 12
Year: 2003
Page: [1051 - 1064]
Pages: 14
DOI: 10.2174/0929867033457629
Price: $65

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