Fluorinated Barbituric Acid Derivatives: Synthesis and Bio-activity

Author(s): Nathalie Moussier, Luca Bruche, Fiorenza Viani, Matteo Zanda

Journal Name: Current Organic Chemistry

Volume 7 , Issue 11 , 2003

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Barbituric acid derivatives exert important action on the central nervous system, and recently have found totally new biomedicinal applications in fields such as cancer and AIDS therapy, and protease inhibitors. On the other hand, selective introduction of fluorine into biologically active compounds can either enhance their pharmacological properties or increase their therapeutic efficiency. This review focuses on the synthesis and the biological properties of fluorinated barbituric acid derivatives, which can be divided into three main categories: 1) those bearing a fluorine directly bound in position 5 of the 2,4,6-trioxohexahydro-pyrimidine ring, 2) 5-fluoroalkyl derivatives, and 3) 5-fluoroaryl derivatives.

Keywords: fluorinated barbituric acid derivatives, barbituric acid derivatives, trioxohexahydro-pyrimidine ring, 5-fluoroaryl derivatives

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Article Details

Year: 2003
Page: [1071 - 1080]
Pages: 10
DOI: 10.2174/1385272033486567
Price: $65

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