The Insulin-sensitizing Role of the Fat Derived Hormone Adiponectin

Author(s): K. L. Heilbronn, R. S. Smith, E. Ravussin

Journal Name: Current Pharmaceutical Design

Volume 9 , Issue 17 , 2003

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Adiponectin is an insulin-sensitizing hormone whose blood concentration is reduced in obesity and type 2 diabetes. Administration of recombinant adiponectin in rodents increases glucose uptake and increases fat oxidation in muscle, reduces fatty acid uptake and hepatic glucose production in liver, and improves whole body insulin resistance. The exact receptor and signaling systems are unknown, however, recent studies suggest adiponectin activates AMPK, a putative master metabolic regulator. Thus, excitement surrounds the potential for adiponectin, or a homologue of adiponectin, as pharamacotherapy agents for patients suffering from the metabolic syndrome and more particularly for individuals with insulin resistance and type 2 diabetes.

Keywords: adiponectin, fatty acid oxidation, insulin sensitivity, type 2 diabetes, hepatic glucose production

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Article Details

Year: 2003
Published on: 01 March, 2012
Page: [1411 - 1418]
Pages: 8
DOI: 10.2174/1381612033454766
Price: $65

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