ISSN (Print): 1871-5265
ISSN (Online): 2212-3989
Volume 20, 6 Issues, 2020
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ISSN (Print): 1871-5265
ISSN (Online): 2212-3989
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"The rewards of genomics research translated into novel drug discovery using both traditional and innovative approaches will be captured in reviews of interest both to academic and applied infectious disease researches."
Harvard Medical School, USA
It is a great pleasure for me working with Bentham Science Publication. Bentham Science Publication “Infectious Disorders – Drug Targets” is one of the best publishers in many fields such as medicinal chemistry , pharmacology…etc, that always aim to develop the pharmaceutical industries.
Hourieh Alkadi (Faculty of Pharmacy, Arab International University, Syrian Arab Republic.)
9 Abstract Ahead of Print are available electronically
136 Articles Ahead of Print are available electronically
Childhood disability is a major global public health issue with an estimated 93 million children living with moderate or
severe disability, mostly in low and middle-income countries (LMICs). Over the past decades we have seen significant interests
and commitments from global health leaders in reducing childhood mortality due to infectious and vaccine preventable
diseases. Most of these initiatives are targeted to reduce childhood mortality particularly neonatal and infant deaths in resource
poor settings. However, as investment on childhood survival goes up, there is an increasing threat of soaring childhood
morbidity including disability as the overall health services and/or infrastructures at primary level in LMICs are not improving
homogenously. These heightened responses to global child survival initiatives might lead to a paradoxical increase in childhood
disability (e.g. cerebral palsy) in LMICs if not planned and prepared early.
Global data suggest that infections are among the leading causes of chronic, developmental disabilities in children. A study
conducted in Bangladesh found that almost one in five children with a disability in rural areas were disabled by an infectious
agents . A systematic review on childhood disabilities in low and middle-income countries suggests that the commonest
causes of hearing impairment (the most frequently studied disability) are meningitis, measles and congenital rubella .
Infections are also prominent among the underlying causes of other disabilities including intellectual impairment, and
contribute to disability during early childhood [1, 3].
A large proportion of children in developing countries suffer from long-term disabilities, many of which are of infectious
origin . These include, inter alia, polio, tetanus, congenital rubella and varicella, Japanese encephalitis, influenza, and
meningococcal, pneumococcal and Haemophilus influenzae type b diseases which are preventable by vaccination.
Unfortunately, not all of these vaccines are used in the national childhood immunisation programmes of LMICs. Systematic
studies to identify each infectious cause and their contribution to total disease, economic and other burdens in disability are
In this special issue we have presented review article [4, 5], systematic review article  as well as original research articles
[7-14] on the crux of infectious disease and childhood disability both in high and low-income settings. There is an interesting
mix of articles ranging from a de novo experimental stud on HSV (Fernandez et al) to applied epidemiological studies on the
immunisation status of children with cerebral palsy (May et al) and their mothers (Khan et al) [8, 10 and 11]. We hope these
articles inform, educate and entertain the readers, and generate further discussions on disability and infection.