Abstract
Herpesviruses are large DNA viruses, which possess a number of advantages as gene delivery vectors. These relate to an ability to package large DNA insertions and establish lifelong latent infections in which the viral genome exists as a stable episome in the nucleus. For gene therapy to become a potential future treatment option, biosafe therapeutically efficient gene transfer is a central, but more and more stringent requirement. This review highlights the progress in development of herpesvirus based vectors, describes their properties as wall as discusses the biosafety concerns that are associated with their use in gene therapy. Thought was also given to biosafety issues pertaining to design and production of herpesvirus vector systems in therapeutic gene delivery.
Keywords: Herpesvirus Vectors, DNA viruses, gene delivery
Current Gene Therapy
Title: Biosafety of Herpesvirus Vectors
Volume: 3 Issue: 6
Author(s): S Gogev, F. Schynts, F. Meurens, I. Bourgot and E. Thiry
Affiliation:
Keywords: Herpesvirus Vectors, DNA viruses, gene delivery
Abstract: Herpesviruses are large DNA viruses, which possess a number of advantages as gene delivery vectors. These relate to an ability to package large DNA insertions and establish lifelong latent infections in which the viral genome exists as a stable episome in the nucleus. For gene therapy to become a potential future treatment option, biosafe therapeutically efficient gene transfer is a central, but more and more stringent requirement. This review highlights the progress in development of herpesvirus based vectors, describes their properties as wall as discusses the biosafety concerns that are associated with their use in gene therapy. Thought was also given to biosafety issues pertaining to design and production of herpesvirus vector systems in therapeutic gene delivery.
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Cite this article as:
Gogev S, Schynts F., Meurens F., Bourgot I. and Thiry E., Biosafety of Herpesvirus Vectors, Current Gene Therapy 2003; 3 (6) . https://dx.doi.org/10.2174/1566523034578159
DOI https://dx.doi.org/10.2174/1566523034578159 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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