Corticotropin Releasing Factor (CRF) Peptide Family and their Receptors: Divergent Actions Influencing Human Physiology

Author(s): E. Karteris, H. S. Randeva, E. W. Hillhouse

Journal Name: Current Genomics

Volume 5 , Issue 6 , 2004

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Corticotropin-releasing factor (CRF) and its related peptides play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two G-protein-coupled receptors encoded by separate genes, termed CRF-R1 and -R2. In this review we focus on the structure, phylogeny, and expression of CRF peptide family. We present up-to-date literature on divergent actions of the CRF peptide family, including stress and behaviour, cardiovascular physiology, energy balance and re pr oduction. We also pr ese nt a br ief over view of CRF rec eptor s inc luding pha rmacologic al aspe cts a nd potential therapeutic interventions for CRF receptors.

Keywords: corticotropin releasing factor, stressful stimuli, protein-coupled receptors, crf peptide family

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Article Details

Year: 2004
Published on: 01 March, 2012
Page: [473 - 481]
Pages: 9
DOI: 10.2174/1389202043348968
Price: $65

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