Combinatorial Protein Biochemistry for Therapeutics and Proteomics

Author(s): David Lowe, Lutz Jermutus

Journal Name: Current Pharmaceutical Biotechnology

Volume 5 , Issue 1 , 2004

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This paper reviews progress towards the customised generation of proteins for applications as therapeutics, diagnostics and in proteomics. It particularly focuses on combinatorial approaches where proteins with pre-defined biochemical and biophysical characteristics are selected from large variant libraries.

Keywords: protein therapeutic, protein engineering, display, directed evolution, alternative frameworks

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Article Details

Year: 2004
Page: [17 - 27]
Pages: 11
DOI: 10.2174/1389201043489585

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PDF: 26