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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Synthesis of Bacteriochlorins and Their Potential Utility in Photodynamic Therapy (PDT)

Author(s): Yihui Chen, Guolin Li and Ravindra K. Pandey

Volume 8, Issue 12, 2004

Page: [1105 - 1134] Pages: 30

DOI: 10.2174/1385272043370131

Price: $65

Abstract

The porphyrins and related tetrapyrrole systems are among the most widely studied of all macrocyclic compounds. In fact, in one capacity or another these versatile molecules have influenced nearly all disciplines in chemistry. In recent years, efforts are underway to develop tetrahydroporphyrin-based (bacteriochlorin) compounds with long wavelength absorption in the range of 700-800 nm as photosensitizers for photodynamic therapy (PDT). This review article summarizes the synthetic methodologies that have been developed for the preparation of a variety of bacteriochlorins, either from porphyrins or chlorin systems.

Keywords: bacteriochlorins photodynamictherapy (pdt), tetrapyrrole systems, photosensitizers


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