Title: Targeting the Chemokine Receptor CXCR3 and Its Ligand CXCL10 in the Central Nervous System: Potential Therapy for Inflammatory Demyelinating Disease?
VOLUME: 1 ISSUE: 2
Author(s):Torben Lykke Sørensen
Affiliation:The MS Clinic, Department of Neurology, University of Copenhagen, Glostrup Hospital, 2600 Glostrup,Denmark.
Keywords:chemokines, chemokine receptors, multiple sclerosis
Abstract: Multiple sclerosis is an inflammatory disease of the CNS and a leading cause of disability. Inflammatory mediators play an orchestrating part in lesional development leading to symptoms. Chemokines -chemoattractant cytokines - regulate the inflammatory composite of the MS lesion. This review focuses on the present data regarding CXCL10 (previously known as IP-10) and CXRC3 in multiple sclerosis, since consistent data has suggested that this chemokine/chemokine receptor pair has a pivotal role in leukocyte recruitment into the central nervous system (CNS) in multiple sclerosis.
