An Expanding Appreciation of the Role Chemokine Receptors Play in Cancer Progression

Author(s): O.M. Zack Howard, Carole L. Galligan

Journal Name: Current Pharmaceutical Design

Volume 10 , Issue 19 , 2004

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The contribution of small molecular weight chemoattractant cytokines (chemokines) and their receptors in the trafficking of tumor, immune and vascular cells pertaining to the development and progression of cancer has begun to be investigated. The current literature indicates that interactions between the immune network, angiogenic and cell survival cascades are important for the trafficking and progression of human cancer and that chemokines and chemokine receptors play a central role in these complex inter-related pathways. Several therapeutic approaches have been reviewed and suggest that the most promising arise from the development of combinations of chemokine receptor antagonists.

Keywords: chemokine receptors, cancer, chemoattractant cytokines, chemokine receptor antagonists

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Article Details

Year: 2004
Page: [2377 - 2389]
Pages: 13
DOI: 10.2174/1381612043383935
Price: $65

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