Abstract
Percutaneous coronary intervention has been hampered by restenosis since its inception. Many research projects including the use of various devices and systemic drug administration have shown disappointing results. The clinical data reported from trials with sirolimus- and paclitaxel- eluting stents have been very promising, such that stents with the capability of drug elution are currently attracting the medical community for the prevention of restenosis. Based on the mechanism of action of the drugs released from the stent and the target of the restenotic process, there may be 4 therapeutic objectives: anti-inflammatory, anti-proliferative, anti-migratory, and pro-endothelial healing. There are many candidate agents for drug-eluting stents, however, it now becomes clear that not all drug-eluting stents are equally effective. This article describe candidate agents which have been tested or currently under investigation, and summarize the latest information.
Keywords: drugs, stent, restenosis
Current Pharmaceutical Design
Title: Local Drug Delivery Using Coated Stents: New Developments and Future Perspectives
Volume: 10 Issue: 4
Author(s): Kengo Tanabe, Evelyn Regar, Chi Hang Lee, Angela Hoye, Willem J. van der Giessen and Patrick W. Serruys
Affiliation:
Keywords: drugs, stent, restenosis
Abstract: Percutaneous coronary intervention has been hampered by restenosis since its inception. Many research projects including the use of various devices and systemic drug administration have shown disappointing results. The clinical data reported from trials with sirolimus- and paclitaxel- eluting stents have been very promising, such that stents with the capability of drug elution are currently attracting the medical community for the prevention of restenosis. Based on the mechanism of action of the drugs released from the stent and the target of the restenotic process, there may be 4 therapeutic objectives: anti-inflammatory, anti-proliferative, anti-migratory, and pro-endothelial healing. There are many candidate agents for drug-eluting stents, however, it now becomes clear that not all drug-eluting stents are equally effective. This article describe candidate agents which have been tested or currently under investigation, and summarize the latest information.
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Cite this article as:
Tanabe Kengo, Regar Evelyn, Lee Hang Chi, Hoye Angela, Giessen J. van der Willem and Serruys W. Patrick, Local Drug Delivery Using Coated Stents: New Developments and Future Perspectives, Current Pharmaceutical Design 2004; 10 (4) . https://dx.doi.org/10.2174/1381612043453289
DOI https://dx.doi.org/10.2174/1381612043453289 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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