Abstract
Analysis of whole genome sequences has revealed that genes constitute only a small fraction of the DNA. The function of the remaining part of the genome is still enigmatic. The role of chromosome structure in gene regulation and maintenance of genome stability is increasingly appreciated, which has led to the hypothesis that large parts of the genome may be dedicated to controlling the formation of specific chromosome conformations. Here we review recent advances in our knowledge of chromosome structure and nuclear organization. We describe possible mechanisms by which genomes encode their spatial conformation, such as the use of specific DNA sequence elements to set up local chromatin structures and the potential exploitation of more global sequence characteristics to influence large-scale chromosome conformation. Complete insight into the processes that govern the spatial conformation of chromosomes will reveal new mechanisms of gene regulation and may also explain the large amount of non-coding DNA in genomes.
Keywords: chromosome condensation, nuclear organization, chromosome territory, long-range interaction, boundary element, insulator, transcription, base composition
Current Genomics
Title: Spatial Organization of Genomes
Volume: 5 Issue: 2
Author(s): N Gheldof and J Dekker
Affiliation:
Keywords: chromosome condensation, nuclear organization, chromosome territory, long-range interaction, boundary element, insulator, transcription, base composition
Abstract: Analysis of whole genome sequences has revealed that genes constitute only a small fraction of the DNA. The function of the remaining part of the genome is still enigmatic. The role of chromosome structure in gene regulation and maintenance of genome stability is increasingly appreciated, which has led to the hypothesis that large parts of the genome may be dedicated to controlling the formation of specific chromosome conformations. Here we review recent advances in our knowledge of chromosome structure and nuclear organization. We describe possible mechanisms by which genomes encode their spatial conformation, such as the use of specific DNA sequence elements to set up local chromatin structures and the potential exploitation of more global sequence characteristics to influence large-scale chromosome conformation. Complete insight into the processes that govern the spatial conformation of chromosomes will reveal new mechanisms of gene regulation and may also explain the large amount of non-coding DNA in genomes.
Export Options
About this article
Cite this article as:
Gheldof N and Dekker J, Spatial Organization of Genomes, Current Genomics 2004; 5 (2) . https://dx.doi.org/10.2174/1389202043489962
DOI https://dx.doi.org/10.2174/1389202043489962 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Big Data in Cancer Research
Cancer is a significant threat to human life and health, remaining a highly aggressive killer. It is a leading cause of death worldwide and represents a crucial medical issue for humanity. However, in the past decade, the effectiveness of new synthetic anticancer agents has not matched the current clinical speculation. ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Combined 3D-QSAR, Pharmacophore and Docking Studies on Benzenesulfonamide Derivatives as Potent 12-Lipoxygenase Inhibitors
Letters in Drug Design & Discovery Anti-Angiogenesis in the Treatment of Genito-Urinary Cancers: Last Updates
Current Angiogenesis (Discontinued) The Emerging Role of Janus Kinase Inhibitors in the Treatment of Cancer
Current Cancer Drug Targets Functional Genomics in Xenopus laevis: Towards Transgene-Driven RNA Interference and Cell-Specific Transgene Expression
Current Genomics Visceral Adipose Tissue and Atherosclerosis
Current Vascular Pharmacology Neoangiogenesis Induced by Progenitor Endothelial Cells: Effect of Fucoidan from Marine Algae
Cardiovascular & Hematological Agents in Medicinal Chemistry Directing Hypoxic Tumor Microenvironment and HIF to Illuminate Cancer Immunotherapy's Existing Prospects and Challenges in Drug Targets
Current Drug Targets Long-circulating Targeted Nanoparticles for Cancer Therapy
Current Nanoscience Emerging Strategies to Strengthen the Anti-Tumour Activity of Type I Interferons: Overcoming Survival Pathways
Current Cancer Drug Targets Cannabinoids as Therapeutic Agents for Ablating Neuroinflammatory Disease
Endocrine, Metabolic & Immune Disorders - Drug Targets Integrating LASSO Feature Selection and Soft Voting Classifier to Identify Origins of Replication Sites
Current Genomics Targeted Radionuclide Therapy of Painful Bone Metastases: Past Developments, Current Status, Recent Advances and Future Directions
Current Medicinal Chemistry Inflammatory Diseases - New Compounds and Treatments
Current Organic Chemistry Mitochondria: A Connecting Link in the Major Depressive Disorder Jigsaw
Current Neuropharmacology Alphavirus Vectors for Gene Therapy Applications
Current Gene Therapy HIV-1 Accessory Proteins: Which one is Potentially Effective in Diagnosis and Vaccine Development?
Protein & Peptide Letters Role of Rifaximin in Inflammatory Bowel Disease Treatment
Mini-Reviews in Medicinal Chemistry Assessing the Gender Differences of Adverse Effects in HIV Infection Treatment Based on FDA AERS Database.
Current Bioinformatics Predictors of Response to TNF Antagonists
Current Pharmaceutical Design Humic Acids as Therapeutic Compounds in Lead Intoxication
Current Clinical Pharmacology