Abstract
Regulation of gene transcription and cell differentiation often induces drastic phenotypes in living organisms. External, precise control over these processes through small organic molecules represents a challenge in chemistry and biology. Our laboratory has been discovering small organic molecules that modulate transcription or differentiation and using them as a tool to understand biological phenomena. This personal perspective summarizes our contributions to chemical biology and chemical genetics in the fields of gene transcription and cell differentiation. Our case studies may foreshadow the promise and the challenge of future drug discovery.
Keywords: small molecule modulation, chemical geentics, transcription, differentiation, adipogenesis
Combinatorial Chemistry & High Throughput Screening
Title: Synthetic Molecules that Modulate Transcription and Differentiation: Hints for Future Drug Discovery
Volume: 7 Issue: 7
Author(s): Motonari Uesugi
Affiliation:
Keywords: small molecule modulation, chemical geentics, transcription, differentiation, adipogenesis
Abstract: Regulation of gene transcription and cell differentiation often induces drastic phenotypes in living organisms. External, precise control over these processes through small organic molecules represents a challenge in chemistry and biology. Our laboratory has been discovering small organic molecules that modulate transcription or differentiation and using them as a tool to understand biological phenomena. This personal perspective summarizes our contributions to chemical biology and chemical genetics in the fields of gene transcription and cell differentiation. Our case studies may foreshadow the promise and the challenge of future drug discovery.
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Cite this article as:
Uesugi Motonari, Synthetic Molecules that Modulate Transcription and Differentiation: Hints for Future Drug Discovery, Combinatorial Chemistry & High Throughput Screening 2004; 7 (7) . https://dx.doi.org/10.2174/1386207043328373
DOI https://dx.doi.org/10.2174/1386207043328373 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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