Prospects for Atomic Resolution and Neutron Crystallography in Drug Design

L.      Coates; D.   A.   A.Myles

Abstract

The number of protein crystal structures being refined to atomic resolution is increasing each year as well as the size of proteins being studied. There are currently 346 structures in the protein data bank which have been refined to or beyond atomic resolution. The benefits of atomic resolution X-ray data are discussed along with a number of structural examples of biomedically relevant proteins. The complementary role of neutron diffraction will also be discussed.

Keywords: Neutron Crystallography, atomic resolution, X-ray

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Current Drug Targets

Title: Prospects for Atomic Resolution and Neutron Crystallography in Drug Design

Volume: 5 Issue: 2

Author(s): L. Coates and D. A. A.Myles

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Keywords: Neutron Crystallography, atomic resolution, X-ray

Abstract: The number of protein crystal structures being refined to atomic resolution is increasing each year as well as the size of proteins being studied. There are currently 346 structures in the protein data bank which have been refined to or beyond atomic resolution. The benefits of atomic resolution X-ray data are discussed along with a number of structural examples of biomedically relevant proteins. The complementary role of neutron diffraction will also be discussed.

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Cite this article as:

Coates L. and A.Myles A. D., Prospects for Atomic Resolution and Neutron Crystallography in Drug Design, Current Drug Targets 2004; 5 (2) . https://dx.doi.org/10.2174/1389450043490613

DOI https://dx.doi.org/10.2174/1389450043490613	Print ISSN 1389-4501
Publisher Name Bentham Science Publisher	Online ISSN 1873-5592

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