Renal Neoplasia in the Hyperparathyroidism-Jaw Tumor Syndrome

Author(s): M. H. Tan, B. T. Teh

Journal Name: Current Molecular Medicine

Volume 4 , Issue 8 , 2004

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Hyperparathyroidism-jaw tumor (HPT-JT) syndrome is a familial multi-tumor syndrome resulting from mutations in the HRPT2 tumor suppressor gene, which encodes a protein product named parafibromin. We review current knowledge of the renal manifestations of the HPT-JT syndrome, and examine recent advances in understanding the biological function of parafibromin.

Keywords: hyperparathyroidism-jaw tumor (hpt-jt)syndrome, renal disorders, cystic kidney disease, mixed epithelial-stromal tumor, hrpt2 tumor suppressor, saccharomyces cerevisiae

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Article Details

Year: 2004
Page: [895 - 897]
Pages: 3
DOI: 10.2174/1566524043359719
Price: $65

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