Therapeutic Potential of Inhibiting Brutons Tyrosine Kinase, (BTK)

Author(s): A. O. Vassilev, F. M. Uckun

Journal Name: Current Pharmaceutical Design

Volume 10 , Issue 15 , 2004

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BTK (Brutons tyrosine kinase) is a member of the TEC family of tyrosine kinases that plays a central but diverse modulatory role in various cellular processes. The unique role of BTK in a multitude of signaling pathways, its function as a dual regulator of apoptosis and its involvement in a number of developmental processes makes BTK a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments. The biochemistry and signaling networks of BTK were well described in numerous detailed reviews written by members of our team and others before us. Therefore in this particular review we are going to concentrate on the possible practical application of previously obtained knowledge to specific diseases and disorders.

Keywords: btk, protein tyrosine kinase, inhibitor, apoptosis, diseases, disorders

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Article Details

Year: 2004
Page: [1757 - 1766]
Pages: 10
DOI: 10.2174/1381612043384475
Price: $65

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