The Recognition of Abnormal Forms of HLA-B27 by CD4+ T Cells

Author(s): Louise H. Boyle, Jane C. Goodall, J. S. Hill Gaston

Journal Name: Current Molecular Medicine

Volume 4 , Issue 1 , 2004

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The MHC class I molecule, HLA-B27 can be expressed as a number of non-conventional forms, in addition to conventional HLA-B27 heterodimers presenting peptide. This has lead to new avenues of research to explain the association of this molecule with SpA. Surprisingly, HLA-B27 transgenic animal models implicated CD4+ T cells, which conventionally interact with MHC class II molecules, not MHC class I molecules, in the pathogenesis of SpA. One hypothesis to explain these finding is that non-conventional forms of HLA-B27, specifically HLA-B27 homodimers, might mimic MHC class II molecules and be recognised by CD4+ T cells. We investigated whether CD4+ T cells from AS patients can interact with HLA-B27, discovering that indeed CD4+ T cells can interact with various forms of HLA-B27. Here we discuss how such interactions between HLA-B27 and CD4+ T cells could occur in vivo and potential contributions of such interactions to the pathogenesis of SpA.

Keywords: HLA-B27, hypothesis, homodimers, T cells

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Article Details

Year: 2004
Page: [51 - 58]
Pages: 8
DOI: 10.2174/1566524043479257

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