The Role of Protein Kinase C-alpha (PKC-α) in Cancer and its Modulation by the Novel PKC-α-Specific Inhibitor Aprinocarsen

Author(s): A- R. Hanauske, Karen Sundell, Michael Lahn

Journal Name: Current Pharmaceutical Design

Volume 10 , Issue 16 , 2004

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As our understanding of tumorigenesis increases, interference with the various signaling pathways of tumor cells has become an attractive approach to arresting tumor cell growth and overcoming chemoresistance. Among many intracellular signaling proteins, protein kinase C (PKC) isoenzymes have been identified as possible targets to render tumor cells more susceptible to apoptosis and growth arrest. We review the known biology of the α-isoenzyme of PKC in different cancers to provide a rational approach for developing targeted therapies using PKC modulators, including aprinocarsen, an antisense oligonucleotide (ASO) against PKC-α.

Keywords: pkc, protein kinase c, cancer, aprinocarsen, bryostatin

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Article Details

Year: 2004
Page: [1923 - 1936]
Pages: 14
DOI: 10.2174/1381612043384376
Price: $65

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