Abstract
MAPK (Mitogen Activated Protein Kinase) pathways mediate fundamental biological processes and have moved into the limelight of drug discovery during the past decade. Here we review the biochemistry and biology of MAPK signalling with a focus on ERK, JNK and p38. We summarise current drug discovery efforts and clinical trials. Further, we critically discuss the rationale behind current strategies of using MAPK pathways as drug targets and suggest new approaches that take the complexity of MAPK signalling networks into account.
Keywords: mitogen activated protein kinase, erk, jnk, p38, signal transduction, drug discovery, clinical trials
Current Pharmaceutical Design
Title: Targeting MAPK Signalling: Prometheus Fire or Pandoras Box?
Volume: 10 Issue: 16
Author(s): Simone Boldt and Walter Kolch
Affiliation:
Keywords: mitogen activated protein kinase, erk, jnk, p38, signal transduction, drug discovery, clinical trials
Abstract: MAPK (Mitogen Activated Protein Kinase) pathways mediate fundamental biological processes and have moved into the limelight of drug discovery during the past decade. Here we review the biochemistry and biology of MAPK signalling with a focus on ERK, JNK and p38. We summarise current drug discovery efforts and clinical trials. Further, we critically discuss the rationale behind current strategies of using MAPK pathways as drug targets and suggest new approaches that take the complexity of MAPK signalling networks into account.
Export Options
About this article
Cite this article as:
Boldt Simone and Kolch Walter, Targeting MAPK Signalling: Prometheus Fire or Pandoras Box?, Current Pharmaceutical Design 2004; 10 (16) . https://dx.doi.org/10.2174/1381612043384420
DOI https://dx.doi.org/10.2174/1381612043384420 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Synthesis and Biological Evaluation of Pyrazole amides fused Combretastatin Derivatives as Anticancer Agents
Current Bioactive Compounds Cadmium and Its Epigenetic Effects
Current Medicinal Chemistry Polymorphisms in Methotrexate Pathways: What Is Clinically Relevant, What Is Not, and What Is Promising
Current Drug Metabolism Novel Approaches for Molecular Targeted Therapy of Breast Cancer: Interfering with PI3K/AKT/mTOR Signaling
Current Cancer Drug Targets Influence of Pulsing Electromagnetic Field Therapy on Gene Expression in Muscle Cells, Peripheral Circulation, and Metabolic Factors in Aging Adults
Current Chemical Biology Cancer Chemoprevention by Targeting the Epigenome
Current Drug Targets Tobacco, Inflammation, and Respiratory Tract Cancer
Current Pharmaceutical Design Current Pathogenesis of Alzheimer’s Disease and Plants Derived Neuroprotective Phytoconstituents: A Comprehensive Review
Current Psychopharmacology Neurotrophins' Modulation by Olive Polyphenols
Current Medicinal Chemistry Hedgehog Signaling and Urological Cancers
Current Drug Targets Gonadotropin-Releasing Hormone (GnRH) Receptors in Tumors: a New Rationale for the Therapeutical Application of GnRH Analogs in Cancer Patients?
Current Cancer Drug Targets PET and SPECT Radiotracers to Assess Function and Expression of ABC Transporters In Vivo
Current Drug Metabolism Evaluation of B Lymphocyte Deficiencies
Cardiovascular & Hematological Disorders-Drug Targets Recent Progress on Antifungal Drug Development
Current Pharmaceutical Biotechnology Novel Scopoletin Derivatives Kill Cancer Cells by Inducing Mitochondrial Depolarization and Apoptosis
Anti-Cancer Agents in Medicinal Chemistry Gene Therapy Targeting in the Central Nervous System
Current Gene Therapy Molecular Mechanisms and Treatment of Radiation-Induced Lung Fibrosis
Current Drug Targets Clearance of Beta-Amyloid in the Brain
Current Medicinal Chemistry Clinical Applications and Biosafety of Human Adult Mesenchymal Stem Cells
Current Pharmaceutical Design Small Molecules with EGFR-TK Inhibitor Activity
Current Drug Targets