Development of Functional Protein Microarrays for Drug Discovery: Progress and Challenges

Author(s): Fang X. Zhou, Jaclyn Bonin, Paul F. Predki

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 7 , Issue 6 , 2004

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Functional protein microarrays promise new approaches to address longstanding challenges in drug discovery and development, with applications ranging from target identification to clinical trial design. However, their widespread adoption will be contingent upon a robust ability to develop and manufacture arrays in support of these applications. This review will address the major areas of relevance to the development of functional protein microarrays; protein content, surface chemistry, manufacture and assay development. Successful development will empower multiple drug research applications, help fill future HTS pipelines and guide next generation combinatorial chemistry efforts.

Keywords: protein microarrays

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Article Details

Year: 2004
Published on: 01 March, 2012
Page: [539 - 546]
Pages: 8
DOI: 10.2174/1386207043328490
Price: $65

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