Atypical Antipsychotics: Pharmacokinetics, Therapeutic Drug Monitoring and Pharmacological Interactions

Author(s): Maria Augusta Raggi, Roberto Mandrioli, Cesare Sabbioni, Vincenzo Pucci

Journal Name: Current Medicinal Chemistry

Volume 11 , Issue 3 , 2004

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Abstract:

The development of new “atypical” antipsychotic agents, which are safer than classical neuroleptics and also active against the negative symptoms and neurocognitive deficits caused by the illness, has produced a significant advancement in the treatment of schizophrenia. The atypical (or “second generation”) antipsychotics have several therapeutical properties in common, however they can significantly differ with regard to clinical potency and side effects. The main features regarding pharmacodynamics, pharmacokinetics and pharmacological interactions of the most important atypical antipsychotics, namely clozapine, olanzapine, quetiapine and risperidone, are treated herein. Several analytical methods available for the therapeutic drug monitoring of these drugs are also presented, as well as the novel formulations, which can notably improve the therapy of schizophrenia. Other very recent atypical agents, such as ziprasidone, aripiprazole, iloperidone, sertindole and zotepine will also be briefly described.

Keywords: atypical antipsychotics, pharmacokinetics, pharmacological interactions, therapeutic drug monitoring, analytical methods

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Article Details

VOLUME: 11
ISSUE: 3
Year: 2004
Page: [279 - 296]
Pages: 18
DOI: 10.2174/0929867043456089
Price: $65

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