Title: Oligonucleotides and Oligonucleotide Conjugates: A New Approach for Cancer Treatment
VOLUME: 12 ISSUE: 1
Author(s):Tatiana Da Ros, Giampiero Spalluto, Maurizio Prato, Tula Saison-Behmoaras, Alexandre Boutorine and Barbara Cacciari
Affiliation:Dipartimento di Scienze Farmaceutiche, Universita di Trieste, Piazzale Europa.
Keywords:antisense oligonucleotides, mrna, Rnase, hybridisation, gene-directed therapy
Abstract: In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and their utilisation in antigene, antisense and decoy approaches, with particular attention to peptide nucleic acids, locked nucleic acids and oligonucleotide conjugates, the most promising compounds in this field.
