Oligonucleotides and Oligonucleotide Conjugates: A New Approach for Cancer Treatment

Author(s): Tatiana Da Ros, Giampiero Spalluto, Maurizio Prato, Tula Saison-Behmoaras, Alexandre Boutorine, Barbara Cacciari

Journal Name: Current Medicinal Chemistry

Volume 12 , Issue 1 , 2005

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In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and their utilisation in antigene, antisense and decoy approaches, with particular attention to peptide nucleic acids, locked nucleic acids and oligonucleotide conjugates, the most promising compounds in this field.

Keywords: antisense oligonucleotides, mrna, Rnase, hybridisation, gene-directed therapy

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Article Details

Year: 2005
Page: [71 - 88]
Pages: 18
DOI: 10.2174/0929867053363603

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