Abstract
In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and their utilisation in antigene, antisense and decoy approaches, with particular attention to peptide nucleic acids, locked nucleic acids and oligonucleotide conjugates, the most promising compounds in this field.
Keywords: antisense oligonucleotides, mrna, Rnase, hybridisation, gene-directed therapy
Current Medicinal Chemistry
Title: Oligonucleotides and Oligonucleotide Conjugates: A New Approach for Cancer Treatment
Volume: 12 Issue: 1
Author(s): Tatiana Da Ros, Giampiero Spalluto, Maurizio Prato, Tula Saison-Behmoaras, Alexandre Boutorine and Barbara Cacciari
Affiliation:
Keywords: antisense oligonucleotides, mrna, Rnase, hybridisation, gene-directed therapy
Abstract: In this account we summarise recent studies on oligonucleotides and oligonucleotide derivatives and their utilisation in antigene, antisense and decoy approaches, with particular attention to peptide nucleic acids, locked nucleic acids and oligonucleotide conjugates, the most promising compounds in this field.
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Ros Da Tatiana, Spalluto Giampiero, Prato Maurizio, Saison-Behmoaras Tula, Boutorine Alexandre and Cacciari Barbara, Oligonucleotides and Oligonucleotide Conjugates: A New Approach for Cancer Treatment, Current Medicinal Chemistry 2005; 12 (1) . https://dx.doi.org/10.2174/0929867053363603
DOI https://dx.doi.org/10.2174/0929867053363603 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
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