Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design

Author(s): Lidia Moreira Lima, Eliezer J. Barreiro

Journal Name: Current Medicinal Chemistry

Volume 12 , Issue 1 , 2005

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This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds.

Keywords: lead compound, isosterism, antagonist, pharmacodynamic, pharmacokinetic, hplc, prostaglandin-h synthase-2 (pghs-

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Article Details

Year: 2005
Page: [23 - 49]
Pages: 27
DOI: 10.2174/0929867053363540

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PDF: 330