Combinatorial Chemistry in Glycobiology

Author(s): Obadiah J. Plante

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 8 , Issue 2 , 2005

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Abstract:

The application of combinatorial chemistry to glycobiology historically has proven challenging due to numerous synthetic hurdles. The advent of novel methodologies has enabled the production of natural as well as mimetic analogues for proof-of-concept experiments and SAR. This review highlights some of the recent synthetic advances in combinatorial carbohydrate synthesis. The application of carbohydrate libraries in glycobiology is also discussed.

Keywords: drug discovery, high-throughput assays, glycobiology, deprotection-coupling cycles, stereoselectivity, gram-negative bacteria

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Article Details

VOLUME: 8
ISSUE: 2
Year: 2005
Page: [153 - 159]
Pages: 7
DOI: 10.2174/1386207053258523
Price: $65

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