Synthetic peptides have a long tradition as molecular tools in biomedical research and drug discovery. The introduction of high-throughput synthesis and screening technologies for synthetic peptides, such as arrays and combinatorial libraries, enabled the large-scale and detailed exploration of protein-ligand interactions, as well as the discovery of novel biologically active peptides. This review summarizes currently available synthetic peptide array and library technologies, in particular mixture-based peptide libraries, which are illustrated by numerous applications in various fields of biomedical research.
Keywords: protein-ligand interactions, protein chips, two-dimensional arrays, synthetic peptide combinatorial libraries, surface plasmon resonance, infectious diseases, signal transduction kinase, phosphotransferase system
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