Ribozymes, DNAzymes and Small Interfering RNAs as Therapeutics

Author(s): M. Sioud, P. O. Iversen

Journal Name: Current Drug Targets

Volume 6 , Issue 6 , 2005

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Selective gene silencing by nucleic acid enzymes has provided researchers with a new strategy to block gene expression and drug target validation. Ribozymes, DNAzymes and small interfering RNAs (siRNAs) are being explored as genetic inhibitors of gene expression as well as potential therapeutics against viral infections, inflammatory disorders, haematological diseases and cancers. We review the mode of action of these molecules, with special emphasis on their construction and the possibility to enhance their serum half-lives via specific chemical modifications. Their potential use in cell cultures and in animal models for disease is also highlighted.

Keywords: dnazyme, ribozyme. rna interference, small interfering rnas

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Article Details

Year: 2005
Page: [647 - 653]
Pages: 7
DOI: 10.2174/1389450054863653
Price: $65

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