Exploiting Novel Cell Cycle Targets in the Development of Anticancer Agents

Author(s): Chung Fai Wong, Alexander Guminski, Nicholas A. Saunders, Andrew J. Burgess

Journal Name: Current Cancer Drug Targets

Volume 5 , Issue 2 , 2005

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In this review we provide a brief background on the cell cycle and then focus on two novel and emerging areas of cell cycle research that may prove to have significant relevance to the development of novel anticancer agents. In particular, we review the emerging evidence to suggest that histone deacetylase inhibitors may possess cancer cell-specific cytotoxicity due to their ability to target a novel G2/M checkpoint. We also review the recent literature supporting the proposition that inhibition of E2F activity in epithelial cancer cells may prove to be a useful differentiation therapy that operates via cell cycle-dependent and cell cycleindependent mechanisms.

Keywords: angiogenesis, dna replication, mitosis, cyclin dependent kinase inhibitors, transcription, phosphorylation

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Article Details

Year: 2005
Page: [85 - 102]
Pages: 18
DOI: 10.2174/1568009053202090
Price: $65

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