Abstract
The area of solid-phase synthesis has witnessed exponential growth in the last fifteen years, but difficulties associated with the monitoring and analysis of resin-bound reactions and products have been apparent due to a limited number of analytical methods available. With the substrate tethered to an insoluble support traditional chromatographic monitoring is only possible after cleavage. In order to address this analytical bottleneck Geysen, in 1996 elaborated Merrifields initial dual linker strategy by incorporating an encoding system between two in-line linkers. These analytical construct resins represented a new approach for both the quality control of solid-phase combinatorial libraries and for the development of new synthetic sequences on solid-support. This review will summarize the development and application of analytical construct resins focusing on recent applications of the technology.
Keywords: analytical constructs, solid-phase organic synthesis, analysis, review
Combinatorial Chemistry & High Throughput Screening
Title: Recent Advances in Analytical Construct Resins
Volume: 8 Issue: 4
Author(s): D. M. Whitehead, S. C. McKeown and A Routledge
Affiliation:
Keywords: analytical constructs, solid-phase organic synthesis, analysis, review
Abstract: The area of solid-phase synthesis has witnessed exponential growth in the last fifteen years, but difficulties associated with the monitoring and analysis of resin-bound reactions and products have been apparent due to a limited number of analytical methods available. With the substrate tethered to an insoluble support traditional chromatographic monitoring is only possible after cleavage. In order to address this analytical bottleneck Geysen, in 1996 elaborated Merrifields initial dual linker strategy by incorporating an encoding system between two in-line linkers. These analytical construct resins represented a new approach for both the quality control of solid-phase combinatorial libraries and for the development of new synthetic sequences on solid-support. This review will summarize the development and application of analytical construct resins focusing on recent applications of the technology.
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Cite this article as:
Whitehead M. D., McKeown C. S. and Routledge A, Recent Advances in Analytical Construct Resins, Combinatorial Chemistry & High Throughput Screening 2005; 8 (4) . https://dx.doi.org/10.2174/1386207054020804
DOI https://dx.doi.org/10.2174/1386207054020804 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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