Abstract
Small research-based pharmaceutical start-ups often lack the budget and do not have the infrastructure available to apply all possible techniques for compound selection. This review details our use of a range of techniques such as high-throughput docking and similarity searching to maximize the success rate when attempting to identify pharmaceutically relevant ligands in a resource-constrained environment.
Keywords: docking methods, murein synthetic pathway, enzymes, murb assay, diversity metrics, pharmacophore
Current Pharmaceutical Design
Title: Discovery Strategies in a BioPharmaceutical Startup: Maximising your Chances of Success Using Computational Filters
Volume: 11 Issue: 3
Author(s): A. Jennings and M. Tennant
Affiliation:
Keywords: docking methods, murein synthetic pathway, enzymes, murb assay, diversity metrics, pharmacophore
Abstract: Small research-based pharmaceutical start-ups often lack the budget and do not have the infrastructure available to apply all possible techniques for compound selection. This review details our use of a range of techniques such as high-throughput docking and similarity searching to maximize the success rate when attempting to identify pharmaceutically relevant ligands in a resource-constrained environment.
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Cite this article as:
Jennings A. and Tennant M., Discovery Strategies in a BioPharmaceutical Startup: Maximising your Chances of Success Using Computational Filters, Current Pharmaceutical Design 2005; 11 (3) . https://dx.doi.org/10.2174/1381612053382151
DOI https://dx.doi.org/10.2174/1381612053382151 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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