Design and Synthesis of Protein Superfamily-Targeted Chemical Libraries for Lead Identification and Optimization

Title: Design and Synthesis of Protein Superfamily-Targeted Chemical Libraries for Lead Identification and Optimization

Volume: 12 Issue: 11

Author(s): Stephen J. Shuttleworth, Richard V. Connors, Jiasheng Fu, Jinqian Liu, Mike E. Lizarzaburu, Wei Qiu, Rajiv Sharma, Malgorzata Wanska and Alex J. Zhang

Affiliation:

Keywords: parallel, combinatorial, gpcr, protease, kinase, nuclear hormone receptor

Abstract: This review chronicles original literature dating back to 1992 outlining the applications of parallel synthesis and combinatorial chemistry to the synthesis of compound libraries focused towards specific superfamilies of molecular targets. Target families that have received significant literature coverage include kinases, proteases, nuclear hormone receptors and cell surface receptors, notably GPCRs.

Cite this article as:

Shuttleworth J. Stephen, Connors V. Richard, Fu Jiasheng, Liu Jinqian, Lizarzaburu E. Mike, Qiu Wei, Sharma Rajiv, Wanska Malgorzata and Zhang J. Alex, Design and Synthesis of Protein Superfamily-Targeted Chemical Libraries for Lead Identification and Optimization, Current Medicinal Chemistry 2005; 12 (11) . https://dx.doi.org/10.2174/0929867054020936