Nucleic Acid Analysis by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry at the Beginning of the Twenty-First Century

Author(s): J. L. Frahm, D. C. Muddiman

Journal Name: Current Pharmaceutical Design

Volume 11 , Issue 20 , 2005

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Abstract:

Mass spectrometers measure an intrinsic property (i.e., mass) of a molecule, which makes it an ideal platform for nucleic acid analysis. Importantly, the unparalleled capabilities of Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry further extend its usefulness for nucleic acid analysis. The beginning of the twenty-first century has been marked with notable advances in the field of FT-ICR mass spectrometry analysis of nucleic acids. Some of these accomplishments include fundamental studies of nucleic acid properties, improvements in sample clean up and preparation, better methods to obtain higher mass measurement accuracy, analysis of noncovalent complexes, tandem mass spectrometry, and characterization of peptide nucleic acids. This diverse range of studies will be presented herein.

Keywords: ft-icr, fourier transform ion cyclotron resonance, mass spectrometry, dna, rna, pna

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Article Details

VOLUME: 11
ISSUE: 20
Year: 2005
Page: [2593 - 2613]
Pages: 21
DOI: 10.2174/1381612054546905
Price: $65

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